While on Xofigo
While on Xofigo
Blood cell count monitoring appointments are very important
Make sure to keep your appointments and be sure to tell your doctor or nurse if you have signs of low blood cell counts, such as:
- More bleeding or bruising than usual after an injury
- Catching more colds than usual
- Feeling short of breath
- Feeling tired
Drink enough fluids
- Tell your doctor if you become dehydrated or experience urinary or kidney problems
Bathroom hygiene is important
Your body removes radioactivity mostly through feces. So, while you are being treated with Xofigo—until at least 1 week after the last injection—you should:
- Wash your hands well every time you go to the bathroom
- Flush the toilet several times after each use
- Make sure that if bodily waste is spilled, it is removed completely and quickly. If bodily waste gets on clothing, wash it right away by itself. Afterward, you should wash your hands very well. Anyone who helps you should wash their hands well, too
- Wear one-use gloves or gowns any time you clean up bodily waste. Dispose of gloves or gowns as directed by your healthcare provider
- Keep your bathroom area clean
Sexual relations during Xofigo therapy
You can have sexual relations while being treated with Xofigo. Because of the possible effect that radiation can have on sperm, you should always use a condom. Also, your female partners should use a very effective form of birth control during your treatment and for 6 months after treatment is over.
Xofigo® (radium Ra 223 dichloride) injection is used to treat prostate cancer that no longer responds to hormonal or surgical treatment that lowers testosterone. It is for men whose prostate cancer has spread to the bone with symptoms but not to other parts of the body.
Important Safety Information
Xofigo is not indicated for women. Women who are pregnant or may become pregnant should not receive Xofigo and should practice safe sex, such as having their partner wear a condom and using effective birth control, as Xofigo can harm unborn babies. People who are handling fluids such as urine, feces, or vomit of a man taking Xofigo should wear gloves and wash their hands as precaution.
Before taking Xofigo, tell your healthcare provider if you:
- have bone marrow problems. Xofigo can cause your blood cells counts to go down, including red blood cells, white blood cells, and/or platelets. In a clinical trial, some patients had to permanently discontinue therapy because of bone marrow problems. In addition, there were some deaths and blood transfusions that occurred due to severe bone marrow problems. Your healthcare provider will do blood tests before and during treatment with Xofigo
- are receiving any chemotherapy or another extensive radiation therapy
- are taking Zytiga® (also known as abiraterone) with prednisone/prednisolone, as this may increase the risk of bone fractures (breaks) and death
- have any other medical conditions
While you are on Xofigo:
- make sure you keep your blood cell count monitoring appointments and tell your healthcare provider about any symptoms or signs of low blood cell counts. Report symptoms or signs of shortness of breath, tiredness, bleeding (such as bruising), or infection (such as fever)
- stay well hydrated and report any signs of dehydration (such as dry mouth and increased thirst), or urinary or kidney problems (such as burning when urinating)
- there are no restrictions regarding contact with other people after receiving Xofigo
- follow good hygiene practices in order to minimize radiation exposure from spills of bodily fluids to household members and caregivers for a period of one week after each injection
- use condoms and make sure female partners who may become pregnant use highly effective birth control methods during and for a minimum of six months after treatment with Xofigo
The most common side effects of Xofigo include:
- swelling of the arms or legs (peripheral edema)
- low blood cell counts
Tell your healthcare provider if you have any side effects that bother you or do not go away.
For important risk and use information about Xofigo, please see the Full Prescribing Information.
You are encouraged to report side effects or quality complaints of products to the FDA by visiting www.fda.gov/medwatch, or call 1‑800‑FDA‑1088.